The Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development (AAMUSTED), was established on August 27, 2020, under Act 1026 of 2020 of the Parliament of the Republic of Ghana.

AAMUSTED was formed from the College of Technology Education, Kumasi (COLTEK) and the College of Agriculture Education (CAGRIC), Asante-Mampong, which were campuses of the University of Education, Winneba.

The University traces its history to the evolution of COLTEK and CAGRIC. COLTEK started as a Technical Teachers College (TTC) in 1966 and later metamorphosed into the Kumasi Advanced Technical Teachers College (KATTC) in 1978.

The College of Agriculture Education on the other hand, evolved from the St. Andrews Training College, Akropong-Akwapim in the Eastern Region, which was established in 1946 by the Presbyterian Church of Ghana (PCG) and the Scottish Mission.

The KATTC and the St. Andrews Training College were part of the seven (7) Diploma-Awarding Institutions which were amalgamated to form the University College of Education, Winneba (UCEW) by PNDC Law 322, in 1992.

UCEW was weaned from the University of Cape Coast and became an autonomous University in 2004, under Act 672 of the Parliament of the Republic of Ghana.