Ho Teaching Hospital is the fifth public Teaching Hospital in Ghana. It was re-commissioned by the Minister of Health, Hon. Kwaku Agyemang Manu as a Teaching Hospital on the 29th April, 2019 after the Hospital went through vigorous accreditation process by all the Health Professional Regulatory Bodies and the Health Facilities Regulatory Authority.

The Hospital was constructed by Kaevener Construction International of United Kingdom and handed over to the Government of Ghana in November 1998. It commenced service delivery in April 1999 on a small scale. In December 2000, the Hospital was officially commissioned as the Volta Regional Hospital by the former President John Jerry Rawlings and his wife. At the time of commissioning, the Hospital was a 240-bed capacity. It is strategically located to provide specialised health care services to the people of the Volta Region and beyond. The Hospital envisioned itself as a Medical Tourist Centre through provision of Innovative Health Care.

The hospital is patronised by clients from the Republic of Togo, Benin and the Federal Republic of Nigeria. With the new status, the Hospital is poised to serve as the premium Medical Tourist centre with Innovative Tertiary Health Care, Medical Education and Research.